The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3495-9. doi: 10.1016/j.bmcl.2004.04.069.

Abstract

3-(N-Alkyl)aminopropylphosphonic acids are potent agonists of four of the five known sphingosine-1-phosphate (S1P) receptor subtypes.

MeSH terms

  • Animals
  • CHO Cells
  • Cricetinae
  • Humans
  • Inhibitory Concentration 50
  • Ligands
  • Organophosphonates / chemical synthesis
  • Organophosphorus Compounds / chemical synthesis
  • Phosphorus Radioisotopes
  • Receptors, G-Protein-Coupled / agonists*
  • Receptors, Lysosphingolipid / agonists*
  • Structure-Activity Relationship

Substances

  • Ligands
  • Organophosphonates
  • Organophosphorus Compounds
  • Phosphorus Radioisotopes
  • Receptors, G-Protein-Coupled
  • Receptors, Lysosphingolipid